Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 19 0.0 0.723 0.208 0.228
biological_process el 19 0.101 0.91 0.618 0.255
biological_process ka 19 0.0 0.698 0.201 0.233
biological_process rf 19 0.0 0.723 0.208 0.228
cellular_component ct 20 0.001 0.868 0.305 0.247
cellular_component el 20 0.162 0.96 0.651 0.267
cellular_component ka 20 0.003 0.886 0.31 0.251
cellular_component rf 20 0.001 0.868 0.305 0.247
disease ct 12 0.002 0.945 0.141 0.302
disease el 12 0.006 0.936 0.11 0.251
disease ka 12 0.001 0.938 0.142 0.307
disease rf 12 0.002 0.947 0.141 0.302
genetic_interaction ct 16 0.025 0.95 0.524 0.287
genetic_interaction el 16 0.027 1.0 0.549 0.265
genetic_interaction ka 16 1.0 1.0 1.0 0.0
genetic_interaction rf 16 0.025 1.0 0.554 0.297
molecular_function ct 20 0.0 0.994 0.461 0.327
molecular_function el 20 0.067 0.944 0.5 0.271
molecular_function ka 20 0.0 0.975 0.462 0.325
molecular_function rf 20 0.0 0.994 0.459 0.33
pathway ct 4 0.056 0.202 0.132 0.054
pathway el 4 0.002 0.151 0.087 0.057
pathway ka 4 0.002 1.0 0.533 0.469
pathway rf 4 0.038 0.157 0.093 0.045
phenotype ct 12 0.001 0.481 0.094 0.145
phenotype el 12 0.225 0.8 0.544 0.15
phenotype ka 12 0.001 0.475 0.089 0.139
phenotype rf 12 0.001 0.481 0.094 0.145
protein_interaction ct 20 0.0 0.668 0.076 0.162
protein_interaction el 20 0.0 0.715 0.073 0.171
protein_interaction ka 20 0.002 1.0 0.701 0.457
protein_interaction rf 20 0.0 0.659 0.074 0.159

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 20 0.0 0.867 0.357 0.32
integration_mean_by_presence el 20 0.015 0.859 0.406 0.253
integration_mean_by_presence ka 20 0.0 0.764 0.137 0.19
integration_mean_by_presence rf 20 0.001 0.352 0.042 0.079
mean ct 20 0.0 0.857 0.303 0.32
mean el 20 0.002 0.798 0.276 0.227
mean ka 20 0.0 0.384 0.083 0.124
mean rf 20 0.0 0.349 0.048 0.085

CDF plots of non integrated kernels

CDF plots of integrated kernels